The blue danger? Interactions and side effects of erectile dysfunction pills explained

Erectile dysfunction (ED), also called impotence, can affect your quality of life by reducing your satisfaction with sex. ED can have many causes, both psychological and physical. ED for physical reasons is quite common in men in old age. There are medications that can help many men to treat ED.

Among the best-known sexual enhancers for men are:

  • Cialis
  • Viagra
  • Kamagra and Super Kamagra
  • Sildenafil
  • Levitra

These prescription drugs increase the nitric oxide level in your blood. Nitric oxide is a vasodilator, which means it increases the size of your blood vessels to increase blood flow. These medications are especially effective in dilating the blood vessels in your penis. More blood in your penis makes it much easier for you to get and maintain an erection when you are sexually aroused.

Interactions and side effects of sexual enhancers and erectile dysfunction medicine

However, these drugs can also have side effects. Here are seven of the most common side effects of ED drugs.

Common side effects of sexual enhancers that you need to consider include

Regardless of which sexual enhancer your doctor prescribes, the following side effects may occur:

  • headaches
  • muscle aches
  • heartburn
  • diarrhoeal diseases
  • Visual changes
  • hearing loss
  • facial irrigation
  • nasal congestion
  • Long lasting erection
  • Decreasing blood pressure
  • auricular fibrillation

If you have any of these side effects, you should always inform your doctor and seek expert advice. In particular, if you have an erection that does not abate – a permanent erection – or any vision or hearing problems, tell your doctor immediately.

How often do these side effects occur?

Erectile dysfunction drugs work by blocking the chemicals (called PDE5) that cause blood to leave an erect penis. This interaction may be associated with some possible side effects. The most common side effects of ED pills like Viagra, Cialis, Sildenafil and Levitra are:

  • Headache (10%-16%)
  • Rinse (5%-12%)
  • Nasal congestion (1%-10%)
  • stomach upset (4%-12%)
  • Dizziness (~3%)

Warning: These side effects of PDE-5 inhibitors need to be treated immediately

You may need emergency treatment if you get an erection that lasts longer than 4 hours and is performed without sexual arousal. You may hear a doctor call it “priapism”. Blood is trapped in the penis and cannot flow out again. It can lead to scarring and permanent ED if not treated.

Also get emergency treatment with one of the following measures:

  • A rash
  • Painful erection
  • itching or burning when urinating
  • faint
  • chest pains

If you have chest pain and have taken Viagra in the last 24 hours or Cialis in the last 48 hours, do not take nitroglycerin. Call an emergency service and make sure that you tell them precisely which potency products you have taken and in what concentration.

The Heart Foundation Herzwochen provides important information material on this subject – especially if you suffer from cardiac insufficiency, wear a pacemaker or are chronically at risk of a heart attack, you should seek advice here.

How to recognize unusually severe side effects of ED pills

When taking sexual enhancers, there are usually minor side effects. However, there are some side effects that are not so common and some can even be dangerous. Severe side effects of ED medications can be:

  • Priapism (erections lasting longer than 4 hours)
  • sudden hearing changes
  • vision loss

Contact your doctor immediately if you have any of these serious side effects.

Some men are more likely to experience these side effects than others. This may be due to different living conditions, body composition, or other medications. In any case, taking this medicine can be considered dangerous.

When you discuss ED treatment with your doctor, it is important to tell him about any medication you are taking and any other health problems you may have. If ED medications are not right for you, your doctor may suggest other treatments, such as surgery or vacuum pumps.

What interactions should I watch for with male enhancement pills?

medicines, dietary supplements, and foods Relevant active substances
Grapefruit Grapefruit(-juice)
Fungicides (antimycotics) Ketoconazol, Itraconazol, Fluconazol, Voriconazol
HIV/AIDS   Saquinavir, Ritonavir Atanazavir, Darunavir, Fosamprenavir, Indinavir, Lopinavir, Nelfinavir and Tipranavir
Antidepressants Nefazodon, Fluvoxamin
CYP3A4 inductors / antibiotics (against bacterial infections) Carbamazepin, Ciprofloxacin, Clarithromycin, Erythromycin, Rifampicin
Pulmonary arterial hypertension (high blood pressure in the pulmonary vessels) Bosentan, Revatio
Potency enhancers in combination Sildenafil (Viagra), Vardenafil (Levitra), Tadalafil (Cialis), Avanafil (Spedra)
Nitrate-containing foods / NO donors (for vasodilatation in circulatory disorders, especially myocardial infarction and angina pectoris) Pentaerythrityltetranitrat, Molsidomin, Glycerintrinitrat, Amylnitrit, Nicorandil, Isosorbidnitrat, Isosorbidmononitrat
Alpha-blockers against high blood pressure or prostate hyperplasia Alfuzosin, Bunazosin, Doxazosin, Phentolamine, Prazosin, Silodosin, Tamsulosin, Terazosin, Urapidil, Yohimbine (blood pressure reduction)
acid blocker Cimetidin
immunosuppressive drugs Tacrolimus

This post is also available in: German

William C. Hilberg
As an author, Mr. Hilberg has published several papers on health issues that have gained international recognition. He is close to nature and loves the seclusion and activity as a freelance journalist. In his function as editor William C. Hilberg manages the entire content of PENP. Our team greatly appreciates his expertise and is proud to have him on board.